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新一代叠氮化物探针
The copper-catalyzed azide-alkyne cycloaddition reaction, or CuAAC, has been used extensively for the conjugation, immobilization, and purification of biomolecules as well as for monitoring various biological processes. Recent advances in design of copper chelating ligands such as THTPA or BTTAA improved kinetics of copper-catalyzed azide-alkyne cycloaddition reaction and greatly increased sensitivity of alkyne detection. In spite of many recent …
Azide Plus 试剂详情介绍一览表
Figure 1). Kinetic comparison of chelating azide and non-chelating conventional azideRecent advances in the design of copper-chelating ligands, such as THPTA or BTTAA that stabilize the Cu(I) oxidation state in aqueous solution, improve the kinetics of the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction and greatly increase the sensitivity of alkyne detection. Copper-chelating ligands have also been shown to increase the biocompatibi…
ClickChemistryTools品牌产品文献推广计划
ClickChemistryTools专注于点击化学领域，致力于打造国际一流的专业领域品牌，提供全面的、创新的、优质的、便捷的科研产品和服务。目前，其高品质产品屡登国际权威期刊，并获得了国际学术界的认可，为进一步推动了品牌本土化的传播，靶点科技（北京）有限公司携手ClickChemistryTools在中国开展品牌和产品宣传的活动。为了感谢和回馈广大中国客户的支持，ClickChemistryTools特设产品文献推广计划，旨在建立产品应用数据库，为广大科研工作者提供产品使用的参考价值。靶点科技期待与您…
Click-&-Go IsoTAG 完整糖肽谱试剂盒
Click-&-Go IsoTAG Kit for Profiling Intact GlycopeptidesWhile there has been much interest in profiling the intact glycoproteome, the complexity of glycoproteoforms (and more broadly, all proteoforms) remains challenging to completely define. Mass spectrometry (MS) is commonly employed for characterization of complex proteomic samples. A popular strategy for protein identification is the bottom-up shotgun proteomics approach. In this method, …
反式–环辛烯– 四嗪（TCO–Tz）点击反应具有超快速动力学
TCO – Tetrazine Ligation(Figure 1). Schematic representation of a TCO–Tz ligation reaction.At low biomolecule concentrations (e.g. < 5 μM) where SPAAC falls short due to modest kinetics (e.g. 0.3 to 2.3 M–1s–1), and where copper–catalyzed alkyne–azide cycloaddition click reaction might compromise system viability, trans–cyclooctene–tetrazine (TCO–Tz) is the reaction pair of choice. This ligation chemistry is based on an inverse–dema…
含二苯并环辛炔(DBCO)的双官能团试剂可通过无Cu(I)的链促烷基叠氮键化(SPAAC)将官能团引入叠氮键标记的分子中
Cu – Free Click Chemistry (SPAAC)(Figure 1). Schematic representation of a SPAAC ligation reaction.The strain promoted alkyne-azide cycloaddition, also termed as the Cu-free click reaction, is a bioorthogonal reaction utilizing a pair of reagents, cyclooctynes and azides that exclusively and efficiently react with each other while remain inert to naturally occurring functional groups such as amines (Figure 1). SPAAC enables labeling a wide varie…