TCO-NHS Ester (equatorial)

货号
规格
价格
品牌
货期
1016-25
25 mg
3100.0
ClickChemistryTools
现询
1016-100
100 mg
9900.0
ClickChemistryTools
现询
1016-1000
1000 mg
42000.0
ClickChemistryTools
现询

TCO-NHS Ester is an amine-reactive building block used for modification of amine-containing molecule in organic media. TCO-NHS ester is supplied as a single equatorial (major, rel-(1S-2S-5E-pR), ref 1 and 4) diastereomer. Specially formulated crystalline provides easy handling and extended shelf life.

Important Product Information:
TCO-NHS Ester is not recommended for labeling of proteins in aqueous buffers due to poor level of activation of labeled proteins (Rahim, M.K., et al., Bioconjugate Chem. 2015, 26, 352-360). TCO-PEG4-NHS Ester is well suited for protein and antibody labeling in aqueous buffers.


分子量
267.28
分子式
C13H17NO5
CAS
1191901-33-3
溶(解)度
DMSO, DMF, DCM, THF, Chloroform
纯度
>95% (HPLC)
外观
White to slightly grey crystalline
储存环境
-20°C. Desiccate
运输条件
Ambient temperature

1. Royzen, M., et al. (2008). A Photochemical Synthesis of Functionalized trans-Cyclooctenes Driven by Metal Complexation. J. AM. CHEM. SOC., 130: 3760-1. [PubMed]

2. Blackman, M.L., et al. (2008). Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity. J. AM. CHEM. SOC., 130: 13518-9. [PubMed]

3. Rahim, M.K., et al. (2015). Enhancing Reactivity for Bioorthogonal Pretargeting by Unmasking Antibody-Conjugated trans-Cyclooctenes. Bioconjugate Chem., 26: 352-60. [PubMed]

4. Rossin, R., et al. (2013). Highly Reactive trans-Cyclooctene Tags with Improved Stability for Diels−Alder Chemistry in Living Systems. Bioconjugate Chem., 24: 1210-7. [PubMed]


       

CoA Lot 2504     


                       

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